Venice
The canals of Venice are one of the most popular and emulated destinations in the world. In it's hay day, Venice was at the center of politics, exploration, and arts and architecture. Today that history is still very much alive and well. The city is unlike any other in the world. The best way to immerse yourself in Venice is to get yourself lost in the alleyways. It's actually quite easy to do and you'll find yourself stumbling into the most interesting places, hidden away from the crowds in Piazzo San Marco.
But while you're wandering, be sure and stop off at some of the must see spots along the way. Of course you can't leave Venice without seeing Saint Mark's Basilica, which is centrally located in Piazza San Marco. Get up early when the light is low and the crowds are thin for the best views and photographic opportunities. Head to Doge's Palace, and also go to the top of the Bell Tower of St. Mark. If you want some great day trips, hop on a boat and go to Murano to see its famous glass blowing. Also, the colored town of Burano is absolutely beautiful and a great place to grab a good pastry. Either of these towns can be reached with a short ferry trip. They can also be combined into one days trip together.
Venice is really a city about atmosphere. While there are no shortage of sights, do not loose what you came here for, which is the unique environment and beautiful setting. While Venice can be crowded as a tourist destination, you can avoid much of these crowds if you get up early. Wake up for sunrise and you'll see the city when it is its most beautiful. The dramatic lighting of the sun coming above the horizon creates an absolutely surreal setting, and it is an experience you will share with very few other tourists. It is possible to see a side of Venice that many tourists miss, you just have to think creatively and plan ahead.